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Pharmacological treatment of post-traumatic stress disorder

Jonathan Bisson is a clinical senior lecturer in psychiatry at Cardiff University (Monmouth House, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK. Email: bissonji{at}cf.ac.uk). He leads the local traumatic stress service and is an active researcher in this field. He was recently co-chair of the Guideline Development Group for the National Institute for Clinical Excellence’s clinical practice guidelines on post-traumatic stress disorder.

Post-traumatic stress disorder (PTSD) causes significant distress and is often associated with markedly reduced functioning. Recent reviews have consistently recommended trauma-focused psychological therapies as a first-line treatment for PTSD. Pharmacological treatments have also been recommended but not as consistently. This article reviews the available trials of the pharmacological treatment of PTSD and discusses their implications.