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Adverse physical effects of alcohol misuse

Guy Barclay is a staff grade psychiatrist at Plummer Court, part of Newcastle upon Tyne’s Drug and Alcohol Services. His special interests include alcohol dependency and the neurochemical basis of craving. Jamie Barbour is a specialist registrar in gastroenterology at City Hospital, Sunderland. His special interests include alcoholic liver disease and the genetics of inflammatory bowel disease. Stephen Stewart is a consultant transplant hepatologist and an honorary clinical lecturer currently working at Freeman Hospital, Newcastle upon Tyne. His main research interest is alcoholic liver disease; other special interests include transplantation. Chris Day is Professor of Liver Medicine and Head of the School of Clinical Medical Sciences, Newcastle University, and an honorary consultant hepatologist with Newcastle upon Tyne Hospitals NHS Foundation Trust. His special interests include alcoholic liver disease, non-alcoholic fatty liver disease and drug-induced liver disease. Eilish Gilvarry is a consultant psychiatrist in addictions, also at Plummer Court (Newcastle upon Tyne Drug and Alcohol Services, Plummer Court, Carliol Place, Newcastle upon Tyne NE1 6UR, UK. Email: eilish.gilvarry{at}ntw.nhs.uk). Her special interests include liaison psychiatry in addictions and young people with addictive problems.

This article outlines the majority of the adverse physical effects that have been described secondary to the consumption of alcohol at levels above recommended sensible limits. These conditions are cited according to the organ system they belong to. Only brief descriptions are provided because of the vastness of this topic. The underlying pathophysiology of tolerance and withdrawal is touched upon as this is of relevance to the psychiatrist. Definitions of the terms used describing alcohol misuse, and sensible upper limits of alcohol consumption are also mentioned.

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