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Advances in Psychiatric Treatment (2003) 9: 202-210
© 2003 The Royal College of Psychiatrists

Sexual side-effects of antidepressant and antipsychotic drugs

David Baldwin and Andrew Mayers

David Baldwin is a senior lecturer in psychiatry and honorary consultant psychiatrist at the Royal South Hants Hospital, University of Southampton (University Department of Mental Health, Brintons Terrace, Southampton SO14 0YG, UK. Tel: (0)2380 825533; fax: (0)2380 234243; e-mail: dsb1{at}soton.ac.uk). His research interests include the treatment of depression and anxiety disorders, sexual dysfunction and the prevention of suicidal behaviour. He has acted as an advisor to pharmaceutical companies that manufacture antidepressant or antipsychotic drugs. Andrew Mayers is a research psychologist at the Royal South Hants Hospital, University of Southampton. His research interests include depression, anxiety disorders, suicide and sleep. The University of Southampton has received grants from pharmaceutical companies to support research into the relationships between mental health problems and their treatment and sexual dysfunction.

Adequate sexual expression is essential to many human relationships and provides a sense of physical, psychological and social well-being. Epidemiological and clinical studies show that depression and schizophrenia are associated with impairment of sexual function and satisfaction, even in untreated patients. Most antidepressant and antipsychotic drugs have adverse sexual effects but it is difficult accurately to identify the incidence of treatment-emergent dysfunction, as disturbances can be reliably detected only from systematic enquiries made at baseline and during treatment. Growing awareness of the adverse effects of psychotropic drugs has led to attempts to use adjuvants or substitute treatments to resolve sexual dysfunction. More studies of the effects of antidepressant and antipsychotic drugs on sexual function are needed.





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Copyright © 2003 The Royal College of Psychiatrists.