Vikram Patel is a reader in international mental health at the London School of Hygiene and Tropical Medicine (NPHIRU, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. e-mail: Vikram.patel{at}lshtm.ac.uk). Athula Sumathipala is an honorary lecturer at the Institute of Psychiatry, London. Both authors are psychiatrists who have been working in South Asia, conducting research into public health aspects of mental disorders, particularly the efficacy and cost-effectiveness of locally available and feasible treatments in primary care, and building research capacity in the region. Both wish to acknowledge the Wellcome Trust for supporting their research on mental disorders in South Asia.
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the presence of physical symptoms that suggest a general medical condition . . . and are not fully explained by a general medical condition, by the direct effects of a substance, or by another mental disorder (American Psychiatric Association, 1994: p. 445).
However, the clinical usefulness of these diagnostic categories for understanding medically unexplained symptoms has been questioned. Bass & Benjamin (1993) conceptualise somatisation as a process, rather than a diagnosis, in which the individual has an inappropriate focus on physical symptoms and psychosocial problems are denied. According to Kleinman & Kleinman (1985)
somatisation is the expression of personal and social distress in an idiom of bodily complaints with medical help seeking (p. 430).
Somatisation, in this context, is not a disease entity but a process whose result is the illness experience of medically unexplained symptoms.
It was often assumed that somatisation was a characteristic of mental disorder in non-Western societies and that this was because non-Western cultures were less accepting of psychological symptoms and mental illness. However, it is now acknowledged that somatic presentations are characteristic of all cultures and, furthermore, that the psychological symptoms of common mental disorders can often be elicited on enquiry (Patel et al, 1998; Araya et al, 2001). Thus, somatisation is a universal phenomenon; indeed, some authors have argued that it is psychologisation, the presentation of common mental disorders as psychological symptoms, that is the more unusual presentation (Goldberg & Bridges, 1988). The most likely explanation for somatisation is that somatic complaints are a direct consequence of common mental disorders; for example, autonomic symptoms may be the result of hyperventilation as a consequence of anxiety. In addition, somatic complaints may be idioms for help-seeking for severe social adversities such as domestic violence. Other reasons for somatisation include the stigma associated with mental illness and the perception (often based on reality) that doctors are more concerned with, and likely to respond to, somatic symptoms.
In this article we use the term somatic complaints to denote physical complaints that are clearly not attributable to a physical disease, and focus our discussion of management on symptoms associated with somatoform disorders.
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Cultural context
Some complaints appear to occur within specific cultural contexts. Cultural factors may influence the way a somatic complaint is described. For example, what might be described as tingling-numbness in one culture may be described as insects crawling on the skin in another. A number of somatic symptoms, especially those related to the heart and to the head, prove to be rich cultural metaphors for fear or grief (Patel, 1995). Cultural factors may also influence the way somatic symptoms are categorised. Perhaps the best known example is neurasthenia, a syndrome characterised by fatigue and other somatic symptoms, which is now diagnosed almost exclusively in East Asia. It seems that fatigue, the defining symptom of neurasthenia, is a culturally sanctioned expression of distress, not only of psychological distress such as depression, but also of social unease (Kleinman & Kleinman, 1985). Finally, cultural factors may influence the choice of somatic complaint, for example the complaint of vaginal discharge in women in South Asia (Patel et al, 2005b).
Aetiology
The importance of the aetiology of somatic complaints in developing countries is underscored by the fact that the epidemiological pattern of the burden of disease is very different. For example, the complaint of fatigue is typically attributed to nutritional deficiencies and, in particular, anaemia, which is common in women on account of menstrual blood loss and poorer nutrition, child-bearing and multiple pregnancies (Lennartsson et al, 1979). As a consequence, physicians are likely to prescribe iron, vitamins, tonics and other nutritional supplements to treat the symptom presumptively. However, this response has been challenged by a recent community study in India that sheds light on the prevalence and risk factors for the complaint of chronic fatigue in women (Patel et al, 2005a). More than 1 in 10 women reported fatigue of at least 6 months duration. The strongest risk factors were socio-economic deprivation, gender disadvantage and poor mental health (Box 1
). There was no association between haemoglobin levels or frank anaemia and the complaint of chronic fatigue.
Box 1 Strongest risk factors for the complaint of chronic fatigue in women in India
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Epidemiological conclusions
Thus, despite widely varying cultural beliefs and epidemiological profiles of disease burden in developing countries, the epidemiology of somatic complaints in these countries is very similar to that in developed countries; the key difference is the
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The evidence base from developed countries
Our search identified trials using problem-solving therapy, cognitive therapy, cognitivebehavioural therapy, reattribution training and brief dynamic psychotherapy for the management of functional somatic symptoms; the most frequently used for this purpose is cognitivebehavioural therapy.
Cognitivebehavioural therapy
Most of the trials we assessed give short-term outcomes only. Although medically unexplained symptoms are mainly seen in primary care settings, most of the trials were carried out in secondary or specialist care. A number of systematic reviews evaluated the use of cognitivebehavioural therapy in the treatment of people with somatic symptoms (e.g. Kroenke & Swindle, 2000; Looper & Kirmayer, 2002). Most of the trials targeted specific syndromes such as irritable bowel or chronic fatigue syndromes. Thus, only a minority of trials specifically focused on general somatisation, which includes people with medically unexplained symptoms and those with hypochondriasis.
The reviews conclude that cognitivebehavioural therapy, delivered in individual or group format, may be efficacious for somatic symptoms whether defined as symptom syndromes or grouped under the broader headings of somatoform disorders. Trials variously found that cognitivebehavioural therapy reduced physical symptoms, psychological distress and disability. Cognitivebehavioural interventions produced effects of moderate to large magnitude and cognitivebehavioural therapy is recommended as the first line of treatment. However, the optimum and minimum duration of treatment and the value of maintenance therapy remain to be established.
Psychodynamic psychotherapy
A systematic review of psychodynamic psychotherapy (Guthrie, 1996) identified three trials, from which it concluded that psychodynamic psychotherapy was effective for the management of chronic pain and irritable bowel syndrome. However, the small number of empirical studies made it difficult to generalise the results to other somatic conditions.
Reattribution training
A trial of reattribution training reported that it was associated with more frequent endorsement by patients that they had received the help they wanted and fewer beliefs that their symptoms had only a physical cause. However, the training did not change the incidence of investigations initiated by the family doctor, prescriptions for psychotropic or non-psychotropic drugs or referrals (Morriss & Gask, 2002).
Patientpractitioner interaction
Apart from specific psychological treatments, there is a growing body of evidence that patienthealth practitioner interaction may have benefits for patients with somatoform disorders. For example, Price (2000) noted that an assessment for psychotherapy might itself have therapeutic effects. Changing patients beliefs about their symptoms may improve a broad range of outcomes, including the symptoms themselves, disability, distress and use of healthcare services. Petrie et al(1995) reported that a rounded clinical assessment might modify cognitive factors such as symptom attribution and improve outcome. Price (2000) concluded that simple cognitive approaches might be able to change cognitions and make meaningful improvements in outcomes. This approach acknowledges that symptoms might have a pathophysiological and a cognitive basis. There is evidence from randomised trials to support the therapeutic effect of explanation, supported only by history-taking and consultation. For example, a consultation in which a patient is given a definite diagnosis and reassurance that they will be better soon is better than one in which they are told that their diagnosis and outcome are uncertain (Thomas, 1987). There is also evidence that the treatment of patients presenting with somatic complaints by general physicians rather than psychiatrists leads not only to improved clinical outcomes, but is also associated with improved physical functioning and reduced healthcare costs (Smith et al, 1995).
The evidence base in developing countries
The strongest evidence base from developed countries is for cognitivebehavioural therapy. A key problem in translating this evidence cross-culturally is the assumption that the underlying cognitions are essentially similar in Western and non-Western cultures and that the concepts underpinning cognitivebehavioural therapy will be valid in different cultural settings. As mentioned above, we are aware of only one published treatment trial for medically unexplained symptoms from developing countries (Sumathipala et al, 2000) and this trial used a cognitivebehavioural approach.
Cognitivebehavioural therapy in Sri Lanka
Primary care attenders at a general out-patient clinic in Sri Lanka who had five or more medically unexplained complaints were randomised to cognitivebehavioural therapy with a psychiatrist or to treatment as usual. Cognitivebehavioural therapy reduced patients distress and symptoms, decreased the number of patient-initiated visits to a doctor and increased patient satisfaction. Three 30-min sessions were found to be the minimum adequate course of treatment. A reduction in symptoms was also found in the control group (routine primary care). The researchers concluded that the opportunity to participate in a detailed assessment and to express their explanatory model of illness1 had a non-specific therapeutic effect.
Cognitive representation of illness
The cognitive representation of illness model (Horne, 1997) describes how an individual constructs an internal representation of what is happening to them when they experience physical or psychological symptoms. It suggests that, no matter what the nature of the symptoms, most people organise their thinking around the five key themes of identity, cause, timeline, consequences and cure/control. These themes are clarified in Box 2
.
Box 2 The five themes of the cognitive representation of illness model
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In terms of this model, the majority of patients in the Sri Lankan trial were not concerned about the identity of their symptoms or their cause; they were mainly concerned only about the timeline, consequences and cure/control. The experiences from this trial suggest that the theoretical model underpinning cognitivebehavioural therapy does have cross-cultural applicability, although (as described below) the specific details of the intervention required modification to suit the local context.
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Clinical management of somatic complaints should aim not only to improve the clinical outcome for the patient and family, but also to minimise the direct and indirect disproportionate healthcare costs incurred by patients with somatoform disorders. In both developed and developing countries individuals with somatic complaints tend to consult specialist and alternative care providers (Sumathipala, 1990; Sharpe & Carson, 2001). However, they seem to dislike psychiatric referral, and it rarely results in effective treatment (Escobar, 1996; Mayou & Sharpe, 1997). Furthermore, the great scarcity of mental health services in developing countries and the considerable stigma associated with the seeking of mental healthcare emphasise that intervention must be delivered in primary care by a community or primary health practitioner. The aim of the chosen intervention should be to contain the patient at the primary care level, by offering regular structured visits to one professional carer, thereby coordinating the care and, hopefully, reducing patient-initiated unstructured visits to different practitioners. Through structured sessions, individuals can be made aware of the psychological component of their condition and helped to reduce unnecessary medical consultations and investigations. The ultimate goal of the treatment should be to reduce the patients distress, symptoms and disability and to reduce or limit inappropriate use of medical services.
A psychological treatment: key elements
In this section we summarise some of the key elements of a psychological treatment approach. The specific approach we describe is adapted from the manual used by one of us (A.S.) with colleagues in a recent trial in Sri Lanka of an intervention delivered by primary care physicians to patients with somatic complaints. The treatment was based on a model of cognitivebehavioural therapy described in an earlier trial (Sumathipala et al, 2000), which adapted methods developed by Salkovskis (1989), Sharpe et al(1992) and Goldberg et al(1989). The adaptations included innovative use of culturally relevant and appropriate psychotherapeutic language and strategies simple enough for use in primary care, but conforming to cognitivebehavioural principles.
The trial involved individuals whose symptoms had been present for more than 6 months (to exclude those with acute somatic complaints who were likely to recover spontaneously). The cognitivebehavioural intervention was administered by primary care physicians. Patients were assessed by a consultant physician at baseline and at 3, 6, 9 and 12 months to identify the number of complaints and visits (after the initial treatment sessions all visits were patient-initiated) at each assessment. Participants in the control groups were also cared for by designated primary care physicians, who offered the same number of contacts received by the intervention groups, thus controlling for any non-specific therapeutic effect of the intervention. The first three sessions of the intervention were mandatory and weekly. The remaining three were optional and fortnightly. Each session lasted for 30 min and the treatment was spread over 9 weeks. The intervention was based on the following key elements (summarised in Box 3
).
Box 3 The key elements of a psychological approach
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Recapitulation of the problem
The first step is recapitulation of the problem using the information obtained during exploration of the patients explanatory model of their illness. This is an important element because it tells the patient that they have been understood, that their distress has been appreciated as genuine and not imagined and that the practitioner can empathise with it. This helps establish rapport, which will eventually lead to a strategic alliance and a paradigm shift from what they might have experienced so far in a protracted journey for relief. At this stage of the treatment it is also important to avoid any suggestion that psychological factors or psychiatric illness play a role. The practitioner should recapitulate the problem and present a summary such as:
Youve come to me today as youve had abdominal pain, headache, chest pain, backache, pain in your right arm and numbness in your fingers for the past 5 years. You cant give an exact name for your illness but believe that working too much caused it. You also feel that your husband is responsible for it, as he never helped you with the housework. You believe that your illness is very serious and suspect it might be cancer. Youve been to eight different doctors and had an ECG, chest and spine X-rays, blood tests, urine tests and many other tests you cant describe. All of those were normal. Most of the doctors told you that there was nothing wrong. However, you are far from happy as the symptoms persist, and you strongly feel that you should have a full-body CT scan. As a result of the symptoms, youre unable to do any housework and have had to quit your permanent job as a cashier.
Acknowledging that the symptoms, distress and disability are genuine
The practitioner should state clearly that they believe the patients complaints and concerns to be genuine and not a sign of malingering. They should then explain that any symptom, irrespective of its cause, can make people worry. This could be phrased as follows:
Its wrong to say that there is nothing wrong. There is something wrong. We will help you find out what it is and guide you to do what is best. We will also try to persuade you to avoid doing harmful things. More importantly, I must tell you that your symptoms do not mean that you are going to die or be permanently disabled. I also assure you that you are not mad, the symptoms are not all in your mind and I know that youre not telling lies.
Explaining the treatment strategy
Next, the practitioner outlines the planned treatment and explains its objectives (Box 4
). The patient is made aware of their own role in making the treatment successful, i.e. the importance of their responsibility for taking control of their condition. They are requested to enter into a verbal contract on the treatment:
Box 4 The ultimate goal of treatment
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It is very important for you to actively take part in the treatment process. I can help you do it but I cannot do it for you. Obviously you cant do it all by yourself and thats why youre here today. I will help you get over the difficult situation you are now in. Your treatment is, in fact, a partnership in which I can teach you what to do, how to do it and what things you should not do. This will enable you to deal with your symptoms yourself instead of depending too much on medical help, which hasnt done a great job for you so far.Let me explain a bit more about the nature of the treatment we would offer you. Youll already have noticed that we spend more time with you here than the doctors youve seen so far, and we also talk more. So, for now, lets call it talking treatment. This treatment is commonly used in other parts of the world. It enables the doctor and the patient to talk not only about the patients symptoms but also about the distress that these cause. It also helps both of us to understand why all these things are happening. So we can exchange and share our views and plan and work together to get over these difficulties. Over the next six sessions youll learn the dos and donts.
The practitioner should also give the patient a handout written in simple language indicating the contents of the first sessions. This should include the treatment goals listed in Box 4
and what the patient is expected to do and not do during the treatment session.
Limiting help-seeking
The practitioner should reassure the patient that if visits are required to any other specialist, the practitioner will arrange them in a coordinated fashion. In addition to getting the patient to agree to work with one professional carer, it is useful to engage only one non-professional carer (for example, the spouse or a family member). The aim is to train this person to be a co-therapist, who can reinforce over the long term the treatment offered in the brief therapeutic sessions. The co-therapists main strategy is to try to discourage the patient from discussing symptoms and worries with different people at different times, as conflicting explanations and advice may add to the confusion. The patient is instructed not to discuss symptoms with anyone except their co-therapist, who is learning how to help them.
Explaining the nature of somatic complaints
The practitioner should explain in simple language the basis of perception of symptoms, saying for example:
Various perceptions or feelings in our bodies are common and, regardless of whether we do something about them or ignore them, in most instances they wane in time. If they persist, we may get more alarmed and often, even without being aware of it, we may start to guess the significance of these symptoms. This can lead to fear, distress, concern or worry, an experience that is often shaped by our own previous episodes of illness or those of our relatives. The more concerned we become, the more vigilant and hence the more we notice the symptoms that worried us in the first place and also things we hadnt noticed before.If we listen hard we pick up faint noises. If we look carefully, we see things we wouldnt see otherwise. Similarly, if were preoccupied with our own body well notice various sensations. For example, you breathe all the time but usually youre not aware of it.
But if you close your eyes and concentrate on your breathing youll feel it. So the more preoccupied you are with symptoms the more youll notice.
Concentrating on the patients explanatory model
The explanatory model offers an alternative approach for understanding the continued distress of individuals with medically unexplained symptoms. The practitioner can construct the patients explanatory model for their illness by using the information that the patient gives during the consultation (Box 5
). This model will be helpful in the development of an appropriate intervention. The practitioner should discuss the patients fears with them and provide appropriate reassurance. Any reasonable fears that have not been addressed should be dealt with accordingly. It is important to explain how other peoples opinions and behaviours can adversely affect distress.
| Box 5 Constructing the patients explanatory model Key clues revealing the patients model:
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Avoiding unnecessary treatment and investigations
It is important to explain why no further symptomatic drug treatments will be encouraged, and why no more blood tests or laboratory tests are needed if the symptoms have already been investigated. The practitioner should also explain the reinforcing effect of unneeded investigations that have negative results. This should be discussed in relation to the lack of relevance of the investigation to the symptoms. If an irrelevant investigation has been carried out and the result is negative, then the doctor may say that there is nothing wrong. However, the patient knows that their symptoms are genuine and may therefore suspect that they have a serious illness which has not been detected by the doctor. This may lead to greater anxiety and to consultations with more doctors. Thus, paradoxically, negative test results can make patients more worried.
The why is an elephant called an elephant? analogy is useful in explaining why more investigations that are likely to lead to more negative findings are not needed. The practitioner draws a sketch of an elephant and asks the patient what it is. Assuming that the patient replies that it is an elephant, the practitioner asks why they say it is an elephant. The patient will then give reasons it has a trunk, tusks and so on. The practitioner then replies:
So, it is an elephant based on specific features of an elephant. It was not by excluding other animals that you came to the conclusion that it is an elephant. The elephant is an elephant not because it is not a cat, a cow, a rat . . . or any other animal.
Encouraging a return to normal activities
The disproportionate distress and disability experienced by patients with somatic complaints may result in the overinvolvement of the family. The patient may be relieved of their usual day-today responsibilities because of their perceived disability. However, this reinforces rather than resolves their beliefs and dysfunctional behaviours. Sometimes patients avoid an activity because they are afraid of provoking symptoms. Sometimes avoidance may be directly attributed to a symptom such as lack of energy. Such behaviour may lead the individual to take time off work, to abandon domestic work or even withdraw from social encounters. Again, the resultant disability will reinforce the fear and concern of potential serious illness.
Diary-keeping and monitoring progress
Diary-keeping is a means of expressing distress and of identifying dysfunctional cognitions. A diary can also used as a basis for monitoring symptoms. From the first session the practitioner should encourage the patient to make regular notes of symptoms, associated thoughts (the cognitions) and related behaviour. They should be given a diary for this purpose. In subsequent sessions, the practitioner should go through the diary entries with the patient and use them to reinforce the teaching of previous sessions.
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Complex psychological principles can be translated into simple components that both patients and non-specialist therapists can understand. The culturally appropriate analogies used in the therapeutic package described here retained the fundamentals of cognitivebehavioural theory. This cross-cultural comparability of the treatment model is important, as it strengthens its validity. Fewer and shorter sessions (compared with standard cognitivebehavioural therapy) delivered by a nonspecialist health practitioner achieved significant clinical improvement. This finding has implications not only in the developing world, where mental health services are scarce, but also in the developed world, where psychological therapy is expensive.
Education of healthcare professionals of all specialties and grades about the burden of medically unexplained symptoms is an important priority. A realistic aim in the management of this common clinical problem is to identify it early and to treat it at whatever level of care the patient presents. To achieve the target of identifying and treating these patients at primary care level, it is crucial to train primary care practitioners in the relevant skills.
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MCQ answers
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