Hostname: page-component-848d4c4894-ndmmz Total loading time: 0 Render date: 2024-05-20T11:31:37.366Z Has data issue: false hasContentIssue false

Pharmacotherapy for anxiety disorders: using the available drugs

Published online by Cambridge University Press:  02 January 2018

Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The treatment of anxiety is one of the more contentious issues in therapeutics. It is also one of the most important, as pathological anxiety is such a common symptom in the population. The recent Office of Population Censuses and Surveys survey of psychiatric morbidity indicated that one in eight of all those interviewed had an anxiety disorder of sufficient severity to receive a formal diagnostic label in the week before interview (Meltzer et al, 1994). Clearly, only a proportion of these should be treated with drugs, and selection for pharmacotherapy is one of the more difficult issues in clinical practice. It is a matter of some concern that changes in the National Health Service are increasingly shifting the onus of responsibility for treatment from the psychiatrist to the general practitioner. As a consequence, it behoves both disciplines to keep liaison active, so that best practice can be maintained from whatever source it is being provided.

Type
Research Article
Copyright
Copyright © The Royal College of Psychiatrists 1997 

References

Amarican Psychiatric Association Task Force (1990) Benzodiazepine Dependence, Toxicity, and Abuse. Washington, DC: American Psychiatric Press.Google Scholar
Ashton, C. H., Rawlins, M. D. & Tyrer, S. P. (1990) A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users. British Journal of Psychiatry, 157, 232238.CrossRefGoogle ScholarPubMed
File, S. E. (1985) Tolerance to the behavioral actions of benzodiazepines. Neuroscience and Biobehavioral Reviews, 9, 113122.CrossRefGoogle Scholar
Goa, K. L. & Heel, R. C. (1986) Zopiclone: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy as a hypnotic. Drugs, 32, 4865.CrossRefGoogle ScholarPubMed
Hallström, C. (ed.) (1993) Benzodiazepine Dependence. Oxford: Oxford University Press.Google Scholar
Hudson, J. I. & Pope, H. G. Jr (1990) Affective spectrum disorder: does antidepressant response identify a family of disorders with a common pathophysiology? American Journal of Psychiatry, 147, 552564.Google ScholarPubMed
Kahn, R. J., McNair, D. M., Lipman, R. S. et al (1986) Imipramine and chlordiazepoxide in depressive and anxiety disorders. II: Efficacy in anxious out-patients. Archives of General Psychiatry, 43, 7985.CrossRefGoogle Scholar
Kathol, R. G., Noyes, R., Slymen, D. J. et al (1980) Propranolol in chronic anxiety disorders: a controlled study. Archives of General Psychiatry, 37, 13611367.CrossRefGoogle ScholarPubMed
Kales, A., Scharf, M. B. & Kales, J. D. (1978) Rebound insomnia: a new clinical syndrome. Science, 201, 10391041.CrossRefGoogle ScholarPubMed
Lader, M. (1988) Clinical pharmacology of non-benzodiazepine anxiolytics. Pharmacology, Biochemistry & Behaviour, 29, 797798.CrossRefGoogle ScholarPubMed
Meltzer, H., Gill, B. & Petticrew, M. (1994) OPCS Surveys of Psychiatric Morbidity in Great Britain. Bulletin No. 1: The Prevalence of Psychiatric Morbidity Among Adults Aged 16–64, Living in Private Households, in Great Britain. London: Office of Population Censuses and Surveys.Google Scholar
Morgan, J. & Tyrer, P. (1994) Treating the somatic symptoms of anxiety. CNS Drugs, 1, 427434.CrossRefGoogle Scholar
Morgan, K. & Oswald, I. (1982) Anxiety caused by a short-life hypnotic. British Medical Journal, 284, 942.CrossRefGoogle ScholarPubMed
Pilowsky, L. S., Ring, H., Shine, P. J. et al (1992) Rapid tranquillisation. A survey of emergency prescribing in a general psychiatric hospital. British Journal of Psychiatry, 160, 831835.CrossRefGoogle Scholar
Power, K. G., Jerrom, D. W. A., Simpson, R. J. et al (1985) Controlled study of withdrawal symptoms and rebound anxiety after six week course of diazepam for generalised anxiety. British Medical Journal, 290, 12461248.CrossRefGoogle ScholarPubMed
Tyrer, P. (1991) The benzodiazepine post-withdrawal syndrome. Stress Medicine, 7, 12.CrossRefGoogle Scholar
Tyrer, P. (1992) Anxiolytics not acting at the benzodiazepine receptor: beta blockers. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 16, 1726.CrossRefGoogle Scholar
Tyrer, P. & Murphy, S. (1987) The place of benzodiazepines in psychiatric practice. British Journal of Psychiatry, 151, 719723.CrossRefGoogle ScholarPubMed
Tyrer, P. & Hallström, C. (1993) Antidepressants in the treatment of anxiety disorder. Psychiatric Bulletin, 16, 7576.CrossRefGoogle Scholar
Tyrer, P., Seivewright, N., Murphy, S. et al (1988) The Nottingham study of neurotic disorder: comparison of drug and psychological treatments. Lancet, ii, 235240.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.